Cryptic and desperate plea for advice

How do (or would) ya'll handle unfair treatment by a superior especially when his or her actions could seriously jeopardize your career? How do you keep it from sucking all of your energy, energy you need to spend on your work? How do you do what you can to fight it then draw the line and redirect your energy toward the major, time-intensive projects you need to complete? How do you put a limit on how much mental space you are going to allow the fuckwit to have? How do you handle the anger and frustration of someone putting you in a deeply unfair situation?

I am thinking voodoo doll, but I welcome any and all suggestions. Help!